Skip to main content
. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Free Radic Biol Med. 2019 Jul 26;143:25–46. doi: 10.1016/j.freeradbiomed.2019.07.024

Figure 11. Mitochondrial DNA copy number.

Figure 11.

HBMECs were treated with control M or TGRL lipolysis products (TL) for 3 h. The relative mitochondrial DNA (mtDNA) copy number was defined as the total amount of mtDNA (ND1, CO1, and Cyb) divided by the total amount of nuclear DNA (B2M) using qRT-PCR analysis. A) TL significantly decreased mitochondrial DNA copy number. B) CPT1A1 siRNA significantly recovered TL-induced mitochondrial DNA copy number or dysfunction. N = 3/treatment group and the values are expressed as means ± SEM, *P≤0.05, TL compared to M group or TL treated CPT1A1 siRNA compared to Scrambled siRNA at the same time point.