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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Pharmacol Ther. 2019 Aug 13;203:107401. doi: 10.1016/j.pharmthera.2019.107401

Table 1.

Targeting the UPR in NAFLD

Molecule Target Mechanism Ref.
4-PBA Chemical chaperone Stabilize misfolded proteins (U. Ozcan, et al., 2006)
TUDCA Chemical chaperone Stabilize misfolded proteins (Lebeaupin, et al., 2015)
Salubrinal PERK Prevent eIF2α dephosphorylation (Kuo, et al., 2012)
GSK2606414 PERK PERK-induced JNK activation (Win, et al., 2015)
FGF21 PERK Reduce eIF2α-ATF4-CHOP signaling (Jiang, et al., 2014)
STF-083010 IRE1α Inhibits RNase activity (Lebeaupin, Vallee, Rousseau, et al., 2018)
4u8C IRE1α Inhibits RNase activity (Tufanli, et al., 2017)
Toyocamycin IRE1α Block XBP1 processing (Takahara, et al., 2017)