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(A) Principal components analysis (PCA) of gene expression profiles in HMC3 cells after exposure to vehicle, estradiol (E2), ketamine, (2R,6R)-HNK, (2S,6S)-HNK, E2+ketamine, E2+(2R,6R)-HNK, and E2+(2S,6S)-HNK. (B) Heatmap showing expression profiles for 2,990 selected genes regulated by E2, ketamine or its metabolites.
