Table 2.

Vancomycin doses required to attain target therapeutic concentration

Neonates
Corrected gestational age	Standard empiric dosing guidelines (for comparison)	Dosing	Daily dosing (mg/kg/day), median (IQR)	P value
<29 w	15	Empiric dosing	14 (13–15)	<.05
		Dose required	37 (29–41)
29–≤35 w	30	Empiric dosing	29 (27–30)
		Dose required	43 (32–49)	<.01
35–≤44 w	45	Empiric dosing	45 (44–47)	.62
		Dose required	47 (45–60)

Infants and children
Age	Standard empiric dosing guidelines (for comparison)	Dosing	Daily dosing (mg/kg/day), median (IQR)	P value
29 d–23 mo	30–80	Empiric dosing	59 (45–60)	.60
		Dose required	61 (58–66)
2–18 y	30–80	Empiric dosing	45 (41–58)	<.05
		Dose required	60 (51–74)

IQR, interquartile range; w, weeks.