Table 3.

Final model parameters

Parameter (units)	Typical value	SE (%CV)	Lower 2.5 percentile CI	Bootstrap median	Upper 97.5 percentile CI
CL (L/h)	31.5	6.4	27.3	31.4	35
BSA on CL a	1.33	12.3	0.991	1.33	1.66
Carboplatin + paclitaxel on CL	−0.441	8.8	−0.51	−0.437	−0.352
Q (L/h)	21.9	6.6	19.7	22	24.6
BSA on Q a	1.33	12.3	0.991	1.33	1.66
Albumin on Q	1.45	34.7	0.603	1.45	2.3
Vc (L)	117	8.4	96.7	115	136
BSA on Vc b	1.39	12.5	1.05	1.39	1.72
Vp (L)	122	3.9	112	121	131
BSA on Vp b	1.39	12.5	1.05	1.39	1.72
IIV_CL (%CV)	36.6	20.8	21.7	35.9	55.9
IIV_Vc(%CV)	36.6	20.4	26.6	36.6	52
IIV_Q (%CV)	60.5	8.3	51.3	60.2	68.6
IIV_Vp (%CV)	36.9	6.3	32.2	36.7	41.5
Corr (Vc, Q)	0.691	NE	0.386	0.663	0.955
Corr (Vc,Vp)	0.941	NE	0.767	0.943	1.001
Corr (Q,Vp)	0.515	NE	0.36	0.524	0.676
Residual error (%CV)	33.2	6.4	29.2	32.9	36.8

BSA, body surface area; CI, confidence interval (2.5th and 97.5th percentiles); CL, clearance; Corr, correlation; CV, coefficient of variation; IIV, interindividual variability; Q, clearance of distribution; SE, standard error; Vc, central volume of distribution; Vp, peripheral volume of distribution;

^a

Effect of BSA on CL and Q set to be the same

$$\mathit{CL}=\theta 1*{\left(\frac{\mathit{BSA}\left(m^2\right)}{1.73}\right)}^{\theta 15}*\left(1+\theta 7*\mathit{\text{ConCarboTax}}\right)$$

$$Q=\theta 3*{\left(\frac{\mathit{BSA}\left(m^2\right)}{1.73}\right)}^{\theta 15}*{\left(\frac{\mathit{ALB}\left(\frac{g}{L}\right)}{40}\right)}^{\theta 13}$$

^b

Effect of BSA on Vc and Vp set to be the same

$$\mathit{Vc}=\theta 2*{\left(\frac{\mathit{BSA}\left(m^2\right)}{1.73}\right)}^{\theta 16}$$

$$\mathit{Vp}=\theta 4*{\left(\frac{\mathit{BSA}\left(m^2\right)}{1.73}\right)}^{\theta 16}$$