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. 2019 Oct 3;105(5):996–1004. doi: 10.1016/j.ajhg.2019.09.011

Figure 4.

Figure 4

Mutant Constructs Fail to Induce MA Currents in HEK-P1KO Cells

(A) Representative stretch-activated currents induced by negative pipette pressure from cells transfected with wild-type or the indicated mutant construct. Corresponding pressure stimulus is illustrated above the current trace. Vertical scale bar: 50 mmHg.

(B) Maximal stretch-activated currents recorded from cells expressing wild-type TMEM63A (n = 7) or the indicated variant of TMEM63A p.Gly168Glu (n = 7), p.Ile462Asn (n = 9), and p.Gly567Ser (n = 7). ∗∗∗p = 0.0002, ∗p = 0.0411, ∗∗p = 0.0031, Dunn’s multiple comparison test.