Table 1.

Similarity between Individuals with Likely Causative De Novo Variants in 28 Different Genes

Gene	Growth		Development		HPO (Mean of Max IC)
	p Value	z-Score	p Value	z-Score	p Value	z-Score
KMT2A	0.0058∗	−2.3523	0.1854	−0.7322	0.0000∗	−4.3303
ARID1B	0.0091∗	−2.1949	0.1600	−0.8220	0.0000∗	−4.3420
ANKRD11	0.0004∗	−2.9911	0.0074∗	−1.2472	0.0000∗	−4.9775
DDX3X	0.0132∗	−2.0547	0.1875	−0.7794	0.0939	−1.3331
DYRK1A	0.0098∗	−2.1117	–	–	0.0000∗	−4.5538
ADNP	0.1497	−1.0288	–	–	0.0668	−1.5174
MED13L	0.0200∗	−1.8917	0.8971	1.0019	0.0132∗	−2.2639
EP300	0.1282	−1.1087	–	–	0.0001∗	−3.7941
SATB2	0.0016∗	−2.5532	–	–	0.0000∗	−3.9988
MECP2	0.1429	−1.0485	–	–	0.5124	0.0511
DYNC1H1	0.8245	0.9138	0.9580	2.0714	0.0200∗	−2.1047
PURA	0.1306	−1.0952	–	–	0.5964	0.2668
CTNNB1	0.4570	−0.1706	–	–	0.2412	−0.6985
ASXL3	0.0068∗	−2.1506	–	–	0.8509	1.0434
SYNGAP1	0.0013∗	−2.5082	0.3651	−0.4461	0.8891	1.2212
SCN2A	0.5408	0.0357	–	–	0.1092	−1.2397
POGZ	0.1678	−0.9488	–	–	0.4933	0.0021
CDK13	0.0032∗	−2.3295	–	–	0.0316∗	−1.9063
STXBP1	0.4528	−0.1809	–	–	0.0702	−1.5038
SETD5	0.0009∗	−2.5731	–	–	0.5510	0.1525
EHMT1	0.0162∗	−1.8967	–	–	0.5816	0.2266
TCF20	0.2386	−0.7364	–	–	0.0495∗	−1.6879
PTPN11	0.0689	−1.3813	–	–	0.0008∗	−3.2996
PPP2R5D	0.2137	−0.8091	–	–	0.0020∗	−3.0120
KAT6A	0.3261	−0.5026	–	–	0.3382	−0.4030
FOXP1	0.1304	−1.0885	–	–	0.0624	−1.5660
CREBBP	0.3879	−0.3471	–	–	0.0063∗	−2.5684
CASK	0.3241	−0.5091	–	–	0.2016	−0.8301

Asterisk (^∗) indicates significant p values (≤0.05).