Fig. 1.

Ser456-to-Leu mutant proteins exhibit punctate structures whereas wild-type proteins exhibit cytoplasmic localization. (A) COS-7 cells were transfected with the plasmid encoding wild-type or mutant RARS with a GFP-tag and were obtained as fluorescence images (green). The dotted outline indicates the periphery of the cell. (B) Percentages of cells with punctate structures are statistically shown (**, p < 0.01 in the Student's t-test; n = 3 fields).