Figure 3.

Disease-free Survival

The percentages of individuals who were disease free over a 60 month period according to whether they had a high proportion (above the median) or low proportion (below the median) of subclonal mutations (A) or of subclonal copy number variations (B). Individuals with a high proportion of subclonal mutations were at a significantly higher risk of relapse than those with a low proportion (p = 0.010), whereas there was no significant association between the proportion of subclonal copy number aberrations and disease-free survival (p = 0.082).