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. 2019 Nov 12;19:305. doi: 10.1186/s12877-019-1308-7

Table 4.

Sensitivity analyses of the relationship between Cognitive measures and Anemiaa

Methods Outcome variable Cross-sectional analyses Longitudinal analyses
β (95%CI) p-value β (95%CI) p-value
1:4 PSM Global Cognition −0.47(− 0.69, − 0.25) < 0.001 −0.22(− 0.44, − 0.01) 0.038
Episodic Memory −0.14(− 0.24, − 0.05) 0.004 −0.15(− 0.25, − 0.05) 0.003
TICS −0.22(− 0.38, − 0.05) 0.009 −0.04(− 0.21, 0.12) 0.590
80 < MCV < 100 Global Cognition −0.48(− 0.71, − 0.24) < 0.001 −0.31(− 0.54, − 0.08) 0.009
Episodic Memory −0.13(− 0.23, − 0.03) 0.014 −0.14(− 0.25, − 0.03) 0.016
TICS −0.20(− 0.37, − 0.03) 0.023 −0.10(− 0.27, 0.08) 0.266
BMI ≥ 18.5 Global Cognition −0.42(− 0.63, − 0.21) < 0.001 −0.22(− 0.42, − 0.02) 0.030
Episodic Memory −0.13(− 0.22, − 0.04) 0.005 −0.15(− 0.25, − 0.06) 0.002
TICS −0.17(− 0.32, − 0.02) 0.031 −0.03(− 0.19, 0.12) 0.653

BMI Body mass index, MCV Mean corpuscular volume, eGFR Estimated glomerular function rate, CI Confidence interval, PSM Propensity Scoring Matching, TICS Telephone Interview of Cognitive Status

Notes:a Anemia was defined as hemoglobin concentrations lower than 13 g/dl for men and lower than 12 g/dl for women; All sensitivity analyses were conducted with the Cognitive Test Scores as the outcome and the baseline dichotomous anemia as the independent variable; All the analyses were adjusted for age, education level, marital status, BMI, cigarette smoking status, alcohol consumption, C reactive protein, total cholesterol, high density lipoprotein cholesterol, chronic pain, MCV, eGFR and associated comorbidities (cancer, kidney, stroke, heart, lung, hypertension, diabetes);