Table 5.
Predictors for microbiological cure among patients who completed treatment
| Variables | Unadjusted OR (95% CI) | P | Adjusted OR (95% CI) | P |
|---|---|---|---|---|
| Age (years) | 0.96 (0.93–1.00) | 0.029 | 0.99 (0.96–1.03) | 0.615 |
| BMI (kg/m2) | 1.13 (0.97–1.32) | 0.112 | ||
| Sex, female | 1.50 (0.76–2.96) | 0.238 | ||
| History of tuberculosis | 0.51 (0.24–1.04) | 0.065 | ||
| MAC species | ||||
| M. avium | Reference | Reference | ||
| M. intracellulare | 0.32 (0.16–0.64) | 0.001 | 0.33 (0.15–0.73) | 0.006 |
| Smear positivity at diagnosis | 0.39 (0.19–0.79) | 0.008 | 0.46 (0.21–1.02) | 0.056 |
| Radiographic pattern | ||||
| Nodular bronchiectatic form | Reference | |||
| Upper lobe cavitary form | 0.87 (0.38–1.98) | 0.738 | ||
| Pulmonary function tests | ||||
| FVC (% predicted) | 1.01 (0.99–1.03) | 0.229 | ||
| FEV1 (% predicted) | 1.00 (0.99–1.02) | 0.801 | ||
| FEV1/FVC (%) | 0.97 (0.94–1.01) | 0.126 | ||
| Maintenance of antibiotics (≥6mo) | ||||
| M only | Reference | Reference | ||
| M + E | 7.58 (2.19–26.26) | 0.001 | 5.74 (1.54–21.42) | 0.009 |
| M + R | 2.98 (0.93–9.57) | 0.067 | 2.43 (0.69–8.58) | 0.168 |
| M + E + R | 7.58 (2.77–20.79) | < 0.001 | 5.12 (1.72–15.24) | 0.003 |
Microbiological cure was defined as maintenance of negative culture conversion at the end of treatment. Assessed among 177 patients who completed treatment
Abbreviations: OR odds ratio, BMI body mass index, MAC Mycobacterium avium complex, FVC forced vital capacity, FEV1 forced expiratory volume in 1 s, M macrolide, E ethambutol, R rifampicin