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TLR7 agonist R837 rescued mice from paralysis and death efficiently after viral infection. Upper panel: A schematic diagram of R837 treatment via an oral or i.p. route after EV-A71 infection. Lower panel: Mice were treated with or without R837 (5.0 μg /g of mouse) at dpi = 1. Significant reduction in clinical score was observed only in the two groups treated with R837. *** p < 0.001. The average clinical scores from different experimental and control groups are plotted against dpi
