Table 2.

Sensitivity, specificity, PPV, NPV, and accuracy of serum FGF19 levels and the existing markers alone and in combination in all the HCC cases

	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)
Single marker
AFP	44.4	96.5	96.4	44.8	61.0
DCP	62.2	95.5	96.9	52.9	70.9
FGF19	53.2	95.1	95.9	48.7	66.6
Double markers
AFP and DCP	73.7	91.7	95.3	61.0	77.6
AFP and FGF19	76.0	91.5	95.1	64.0	80.9
DCP and FGF19	81.3	91.0	95.4	68.8	82.5
Multiple markers
AFP, DCP, and FGF19	87.5	87.2	94.0	76.3	85.7