Table 3.

Sensitivity, specificity, PPV, NPV, and accuracy of serum FGF19 levels and the existing markers alone and in combination in small HCC cases

	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)
Single marker
AFP	30.4	96.5	80.7	74.1	74.9
DCP	33.3	95.5	79.3	73.4	71.1
FGF19	55.0	95.1	84.4	79.9	82.0
Double markers
AFP and DCP	53.6	91.7	77.1	79.2	75.4
AFP and FGF19	68.1	91.5	79.7	85.5	83.9
DCP and FGF19	66.7	91.0	79.3	84.0	79.1
Multiple markers
AFP, DCP, and FGF19	75.4	87.2	75.3	87.2	80.1