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. 2019 Oct 4;18:661–672. doi: 10.1016/j.omtn.2019.09.026

Figure 2.

Figure 2

Showing Binding of Aptamer Pool and Monoclonal Aptamer Candidate to MS and CD-based Structural Evaluation of Aptamer Structure

(A) Relative binding of various aptamer pools (rounds 2, 4, and 6–10 and RDL) to target MS as determined by aptamer-linked immobilized sorbent assay (ALISA). (B) Relative binding of various monoclonal aptamers with MS. The aptamers highlighted in blue were selected for further characterization based on an arbitrary cutoff OD450nm ≥ 0.6. (C) CD spectra of MS aptamer candidates.