Figure 4.

Showing Relative IC₅₀ of Aptamer and Known MS Inhibitors and Ki of MS10 and MS10-Trunc

(A) Determination of IC50 of MS10, MS10-Trunc aptamers and known MS inhibitors (BP and PEP). The relative activity of the Mtb-MS as a function of the various concentrations of inhibitory aptamers MS10 and its truncated form MS10-Trunc or known MS inhibitors (BP and PEP). (B and C) K_i value and inhibition mechanism of aptamer MS-10 (B) and its derivative MS10-Trunc (C) were determined using double-reciprocal Lineweaver-Burk plot.