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. Author manuscript; available in PMC: 2019 Nov 12.
Published in final edited form as: Mod Pathol. 2019 Jun 7;32(10):1551–1562. doi: 10.1038/s41379-019-0289-6

Figure 1.

Figure 1.

Histological patterns and DNA mismatch repair protein immunohistochemistry of colorectal carcinomas with double somatic mismatch repair gene mutation/alteration. Case #2 (A-D) exhibits a medullary pattern with tumor cells growing in sheets and nests, and containing easily discernible tumor-infiltrating-lymphocytes (A). By immunohistochemistry, this tumor shows loss of MSH2 (B) and MSH6 (C), and retained MLH1 (not illustrated) and PMS2 (D). Case #6 (E-H) exhibits well formed glands with only very mildly elevated tumor-infiltrating-lymphocytes (E). By immunohistochemistry, this tumor shows loss of MSH2 (F) and MSH6 (G), and retained MLH1 (not illustrated) and PMS2 (H). Case #7 (I-L) exhibits a solid growth with high grade cytology and inconspicuous tumor-infiltrating-lymphocytes (I). By immunohistochemistry, this tumor shows retained MSH2 (J), loss of MSH6 (K), and retained MLH1 (not illustrated) and PMS2 (L).