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CDDO-Me elevated both mRNA and protein levels of Nrf2 in the infarcted heart. (A) Quantitative reverse-transcription polymerase chain reaction data show CDDO-Me increases the Nrf2 transcription in the heart (n = 6, ±S.E.M.). Typical immunoblots (B) and pooled data (C) showing CDDO-Me induced the translational increase of Nrf2 in the noninfarcted left ventricle 2 weeks post CDDO-Me administration (n = 7, ±S.E.M.). GAPDH, glyceraldehyde-3-phosphate dehydrogenase.
