TABLE 1.
Echocardiographic analysis of CHF rats treated with CDDO-Me at 14 weeks post thoracic surgery
| Parameters | Sham+Veh (n = 7) | Sham+CDDO-Me (n = 7) | CHF+Veh (n = 8) | CHF+CDDO-Me (n = 8) |
|---|---|---|---|---|
| Volume; s (µl) | 189.4 ± 83.9 | 213.6 ± 77.0 | 537.0 ± 136.9* | 570.0 ± 279.5 |
| Volume; d (µl) | 596.3 ± 231.3 | 546.4 ± 188.3 | 820.0 ± 226.0 | 953.1 ± 391.5 |
| Stroke volume (µl) | 406.9 ± 155.5 | 332.8 ± 116.1 | 232.1 ± 52.4** | 425.2 ± 249*** |
| Ejection fraction (%) | 68.5 ± 4.1 | 60.7 ± 3.8 | 34.2 ± 8.5ξ | 39.2 ± 15.9 |
| Fractional shortening (%) | 29.7 ± 11.4 | 31.8 ± 12.6 | 13.8 ± 7.2ψ | 18.2 ± 7.0 |
| Cardiac output (ml/min) | 142.7 ± 58.3 | 152.5 ± 15.7 | 30.7 ± 85.7ω | 174.3 ± 81.6△ |
| Infarct size (%) | ─ | ─ | 36.2 ± 8.3 | 29.6 ± 8.1 |
*
P < 0.0001 vs. Sham+Veh; **P < 0.03 vs. Sham+Veh; ***P < 0.05 vs. CHF+Veh; ξP < 0.0001 vs. Sham+Veh; ψP < 0.01 vs. Sham+Veh; ωP < 0.02 vs. Sham+Veh; △P < 0.01 vs. CHF+CDDO-Me.