Fig. 2.

Anatomical patterns of brainstem pathology based on vertex analyses correcting for age, gender, education and total intracranial volumes. Shape deformation in ALS are shown compared to healthy controls (A), disease controls (B) and PLS patients (C). 3D brainstem mesh is presented in blue (A), green (B) and pink (C). Patterns of atrophy is illustrated in orange with respect to healthy controls (A), in red with reference to disease controls (B) and blue in comparison to PLS patients (C). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)