Table 1.
Detected cancers and PCCRC-3yr rate in relation to characteristics of study population and type of colonoscopy. Values are No (%) unless stated otherwise
| Characteristic | Colonoscopies with colorectal cancer diagnosed within three years | PCCRC-3yr rate (%) | ||
|---|---|---|---|---|
| Total | True positive | False negative | ||
| Total | 126 152 | 116 835 | 9317 | 7.4 |
| Year of colonoscopy | ||||
| 2005-07 | 31 336 | 28 711 (25) | 2625 (28) | 8.4 |
| 2008-10 | 44 165 | 40 856 (35) | 3309 (36) | 7.5 |
| 2011-13 | 50 651 | 47 268 (40) | 3383 (36) | 6.7 |
| Age at colonoscopy | ||||
| ≤60 | 22 185 | 20 731 (18) | 1454 (16) | 6.6 |
| 61-70 | 38 521 | 36 153 (31) | 2368 (25) | 6.1 |
| 71-80 | 42 833 | 39 479 (34) | 3354 (36) | 7.8 |
| >80 | 22 613 | 20 472 (18) | 2141 (23) | 9.5 |
| Sex | ||||
| Male | 73 459 | 68 344 (58) | 5115 (55) | 7.0 |
| Female | 52 693 | 48 491 (42) | 4202 (45) | 8.0 |
| IMD income category | ||||
| Most affluent | 27 180 | 25 169 (22) | 2011 (22) | 7.4 |
| 2 | 28 331 | 26 246 (22) | 2085 (22) | 7.4 |
| 3 | 26 479 | 24 533 (21) | 1946 (21) | 7.3 |
| 4 | 23 857 | 22 078 (19) | 1779 (19) | 7.5 |
| Least affluent | 20 305 | 18 809 (16) | 1496 (16) | 7.4 |
| Charlson comorbidity score | ||||
| 0 | 93 684 | 87 738 (75) | 5946 (64) | 6.3 |
| 1 | 21 576 | 19 590 (17) | 1986 (21) | 9.2 |
| 2 | 6438 | 5715 (5) | 723 (8) | 11.2 |
| ≥3 | 4454 | 3792 (3) | 662 (7) | 14.9 |
| Inflammatory bowel disease | ||||
| No | 123 428 | 108 893 (98) | 8348 (90) | 6.8 |
| Yes | 2724 | 1756 (2) | 968 (10) | 35.5 |
| Diverticular disease | ||||
| No | 94 437 | 88 813 (76) | 5624 (60) | 6.0 |
| Yes | 31 715 | 28 022 (24) | 3693 (40) | 11.6 |
| Previous colorectal cancer | ||||
| No | 124 513 | 115 708 (99) | 8805 (95) | 7.1 |
| Yes | 1639 | 1127 (1) | 512 (5) | 31.2 |
| Previous colonoscopy | ||||
| No | 105 972 | 100 541 (86) | 5431 (58) | 5.1 |
| Yes | 20 180 | 16 294 (14) | 3886 (42) | 19.3 |
| Colonoscopy within BCSP | ||||
| No | 109 512 | 100 788 (86) | 8724 (94) | 8.0 |
| Yes | 16 640 | 16 047 (14) | 593 (6) | 3.6 |
| Colonoscopy by independent provider | ||||
| No | 124 143 | 115 013 (98) | 9130 (98) | 7.4 |
| Yes | 2009 | 1822 (2) | 187 (2) | 9.3 |
| Cancer characteristics | ||||
| Stage: | ||||
| I | 21 474 | 19 597 (17) | 1877 (20) | 8.7 |
| II | 34 605 | 32 613 (28) | 1992 (21) | 5.8 |
| III | 33 240 | 31 186 (27) | 2054 (22) | 6.2 |
| IV | 13 564 | 12 252 (10) | 1312 (14) | 9.7 |
| Unknown | 23 269 | 21 187 (18) | 2082 (22) | 8.9 |
| Colonic location: | ||||
| Rectum | 31 492 | 29 496 (25) | 1996 (21) | 6.3 |
| Distal colon | 40 783 | 38 450 (33) | 2333 (25) | 5.7 |
| Proximal colon | 27 383 | 25 143 (22) | 2240 (24) | 8.2 |
| Caecum | 20 978 | 19 057 (16) | 1921 (21) | 9.2 |
| Colon NOS | 5516 | 4689 (4) | 827 (9) | 15.0 |
BCSP=English NHS bowel cancer screening programme; IMD=index of multiple deprivation; NOS=not otherwise specified; PCCRC-3yr=post-colonoscopy colorectal cancer within three years of colonoscopy.