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Disease stage classification criteria
| Classification | ALT | HBV DNA | HBeAg |
|---|---|---|---|
| Immune active (IA) | Elevated | >20 000 IU/mL | Positive |
| >2000 IU/mL | Negative | ||
| Inactive CHB (IC) | Normal | low HBV DNA level | Negative |
| Immune tolerance (IT) | Normal | >1 million IU/mL | Positive |
| Gray zone (GZ) | Not classified as IC, IT or IA | ||
Notes: Upper limit of normal (ULN) of ALT: 30 U/L for males and 19 U/L for females
