OxyContin® (reformulated) |
Oxycodone OP |
Results support that, relative to original OxyContin, there is an increase in the ability of reformulated OxyContin to resist crushing, breaking, and dissolution using a variety of tools and solvents
The results of these studies also support this finding for reformulated OxyContin relative to IR oxycodone
When subjected to an aqueous environment, reformulated OxyContin gradually forms a viscous hydrogel (ie, a gelatinous mass) that resists passage through a needle
|
Embeda®
|
Morphine‐naltrexone |
|
Targiniq™ ER |
Oxycodone‐naloxone ER |
Laboratory test data demonstrate that Targiniq ER can be crushed and dissolved in solution
However, complete separation or complete inactivation of naloxone from oxycodone was not achieved despite using various techniques and conditions
|
Hysingla® ER |
Hydrocodone ER |
Results support that Hysingla ER resists crushing, breaking, and dissolution using a variety of tools and solvents and retains some ER properties despite manipulation
When subjected to an aqueous environment, Hysingla ER gradually forms a viscous hydrogel (ie, a gelatinous mass) that resists passage through a hypodermic needle
|
MorphaBond™ ER |
Morphine‐ARER |
The laboratory test data demonstrated that, relative to morphine sulfate extended‐release tablet, MorphaBond ER has increased resistance to cutting, crushing, or breaking using a variety of tools
When subjected to a liquid environment, the manipulated MorphaBond ER formulation forms a viscous material that resists passage through a needle
|
Xtampza® ER |
Oxycodone DETERx®
|
Results support that, relative to IR oxycodone tablets, Xtampza ER is less susceptible to the effects of grinding, crushing, and extraction using a variety of tools and solvents
Xtampza ER resisted attempts to pass the melted capsule contents or the microspheres suspended in water through a hypodermic needle
|
Arymo® ER |
Morphine‐ADER‐IMT |
Arymo ER tablets, in comparison to morphine sulfate ER tablets, have increased resistance to cutting, crushing, grinding, or breaking using a variety of tools
When subjected to a liquid environment, the manipulated Arymo ER tablets form a viscous hydrogel (ie, a gelatinous mass) that resists passage through a hypodermic needle
|