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. 2019 Nov 5;10:2552. doi: 10.3389/fimmu.2019.02552

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Copyright © 2019 Herzog, Dach, de Buhr, Niemann, Schlagowski, Chaves-Moreno, Neumann, Goretzko, Schwierzeck, Mellmann, Dübbers, Küster, Schültingkemper, Rescher, Pieper, von Köckritz-Blickwede and Kahl.

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Nuclease activity in different S. aureus strains analyzed by DNase agar plates. (A) S. aureus strain AH1263, positive control, showed large clearing zones (white arrow) around colonies. (B) S. aureus strain AH1680 (Δnuc), negative control, presented without clearing zones (white arrow). (C) The early CF S. aureus isolate showed small clearing zones around colonies (white arrow), whereas (D) the late isolate revealed large clearing zones around colonies (white arrow). (E) S. aureus small colony variants (SCVs) did not reveal clearing zones around single colonies (white arrow).