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. 2019 Nov 5;10:2552. doi: 10.3389/fimmu.2019.02552

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Copyright © 2019 Herzog, Dach, de Buhr, Niemann, Schlagowski, Chaves-Moreno, Neumann, Goretzko, Schwierzeck, Mellmann, Dübbers, Küster, Schültingkemper, Rescher, Pieper, von Köckritz-Blickwede and Kahl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of S. aureus nuc1 in an early, intermediate and late S. aureus isolate from patient 1. For the assessment of nuc expression, isolates (Figure 4, in red) were grown in BHI medium until mid-logarithmic growth phase before RNA extraction. Expression of nuc1 increased significantly over time of S. aureus persistence. The obtained results are in line with the nuclease FRET assay detecting low nuclease activity for isolate no. 17 (2001, 15.9%), an intermediate activity for no. 54 (2008, 45.5%), and a high nuclease activity for the late isolate no. 82 (2012, 56.84%). Statistical analysis: two-tailed, unpaired student's t-test, error bars represent SD. Technical replicates n = 2, biological replicates n = 3.