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. 2019 Nov 5;10:2552. doi: 10.3389/fimmu.2019.02552

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Copyright © 2019 Herzog, Dach, de Buhr, Niemann, Schlagowski, Chaves-Moreno, Neumann, Goretzko, Schwierzeck, Mellmann, Dübbers, Küster, Schültingkemper, Rescher, Pieper, von Köckritz-Blickwede and Kahl.

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Analysis of nuclease activity on DNase agar plates after the transformation of the early S. aureus isolate with low nuclease activity of patient 1 with the plasmid pCM28nuc. (A) The early S. aureus isolate with low nuclease activity (Figure 4, isolate17) shows minimal clearance zones (white arrow) around colonies. (B) The pCM28nuc-transformed early S. aureus isolate exhibits large clearance zones, (C) similar to the corresponding late S. aureus isolate with high nuclease activity (Figure 4, isolate 81).