Table 1.
Blood biochemistry in WT and Uox‐KO mice. Biochemical indicators in WT and Uox‐KO mice (n = 8 per group, males, 16 weeks of age). Data were shown as mean ± SEM. Differences between groups were analyzed by the student's t test and one‐way analysis of variance followed by Newman–Keuls multiple comparison test
| WT | KO | P value | WT‐collared | KO‐collared | P value | KO‐collared + allopurinol | P value (compared to KO‐collared) | |
|---|---|---|---|---|---|---|---|---|
| Uric acid (μmol·L−1) | 176.3 ± 6.7 | 563.9 ± 16.9 | < 0.001 | 187.5 ± 4.9 | 573.0 ± 16.4 | < 0.001 | 325.8 ± 9.2 | < 0.001 |
| BUN (mmol·L−1) | 4.47 ± 0.16 | 10.04 ± 0.35 | < 0.001 | 5.19 ± 0.28 | 10.42 ± 0.42 | < 0.001 | 7.91 ± 0.63 | 0.005 |
| Creatinine (μmol·L−1) | 16.53 ± 1.67 | 23.63 ± 2.18 | 0.04 | 15.36 ± 1.83 | 30.5 ± 0.97 | < 0.001 | 21.77 ± 2.47 | 0.0047 |
| Fasting glucose (mmol·L−1) | 6.0 ± 0.2 | 6.3 ± 0.2 | 0.25 | 6.1 ± 0.2 | 6.2 ± 0.2 | 0.71 | 6.4 ± 0.3 | 0.6 |
| TC (mmol·L−1) | 3.36 ± 0.12 | 3.67 ± 0.13 | 0.1 | 3.59 ± 0.08 | 3.85 ± 0.12 | 0.08 | 3.62 ± 0.14 | 0.23 |
| TGs (mmol·L−1) | 1.49 ± 0.16 | 1.13 ± 0.03 | 0.03 | 1.35 ± 0.07 | 1.23 ± 0.03 | 0.13 | 1.27 ± 0.06 | 0.62 |
| HDL cholesterol (mmol·L−1) | 1.61 ± 0.13 | 1.74 ± 0.05 | 0.35 | 1.60 ± 0.05 | 1.80 ± 0.08 | 0.06 | 1.59 ± 0.13 | 0.21 |
| LDL cholesterol (mmol·L−1) | 0.49 ± 0.07 | 0.55 ± 0.04 | 0.44 | 0.48 ± 0.06 | 0.55 ± 0.06 | 0.43 | 0.50 ± 0.03 | 0.44 |