Table 2.
Individual and mean (±SD) kinetic parameters for the four subjects. Between‐subject variation is mostly evident in several apoB48‐ and apoB100‐related FCR values. Between‐subject variability exists in basal and total apoB48 production rates. All subjects have low basal apoB48‐TG rates. Mean apoB100 production rate in VLDL1 and VLDL2 is in line with previously published results 5. FCR, fractional catabolic rate, FDC, fractional direct catabolism, FTR, fractional transfer rate, prod, production, dir, direct, tot, total. Postprandial prod refers to the incremental secretion in response to the test meal in addition to the basal secretion. For explanation of calculations of FCR, FDC and FTR, see Appendix S1
| Subject 1 | Subject 2 | Subject 3 | Subject 4 | Mean ± SD | Mean ± SD second cohort | |
|---|---|---|---|---|---|---|
| ApoB48 kinetic parameters | ||||||
| ApoB48 tot prod (mg day−1) | 248 | 416 | 142 | 327 | 283 ± 100 | 332 ± 99 |
| ApoB48 basal prod (mg day−1) | 27.8 | 27.3 | 57.4 | 101 | 53.4 ± 30 | 61.8 ± 4.3 |
| ApoB48 postprandial prod (mg day−1) | 220 | 388 | 85 | 226 | 230 ± 110 | 270 ± 96 |
| ApoB48 tot FCR (pools day−1) | 17.5 | 27.5 | 3.0 | 2.0 | 12.5 ± 11 | 6.3 ± 2.2 |
| ApoB48 CM FCR (pools day−1) | 49.9 | 26.5 | 4.5 | 5.1 | 21.3 ± 19 | 24.6 ± 21 |
| ApoB48 VLDL1 FCR (pools day−1) | 1.5 | 5.0 | 1.7 | 1.5 | 2.4 ± 1.5 | 12.3 ± 8.8 |
| ApoB48 VLDL2 FCR (pools day−1) | 3.8 | 19 | 3.0 | 0.9 | 6.7 ± 7.2 | 10.7 ± 2.4 |
| ApoB48‐TG kinetic parameters | ||||||
| TG apoB48 tot prod (g day−1) | 67.8 | 67.1 | 68 | 67.7 | 67.6 ± 0.3 | 54.8 ± 0.38 |
| TG apoB48 basal prod (g day−1) | 1.3 | 0.6 | 1.5 | 1.2 | 1.1 ± 0.3 | 0.78 ± 0.37 |
| TG apoB48 postprandial prod (g day−1) | 66.5 | 66.5 | 66.5 | 66.5 | 66.5 ± 0 | 53.2 ± 0.37 |
| TG apoB48 CM FCR (pools day−1) | 238 | 44 | 55 | 23.5 | 83.4 ± 90 | 44 ± 15 |
| TG apoB48 VLDL1 FCR (pools day−1) | 3.4 | 23.2 | 2.5 | 3.1 | 8.1 ± 8.8 | 4.6 ± 3.6 |
| TG apoB48 VLDL2 FCR (pools day−1) | 12.9 | 23.1 | 4 | 1.3 | 10.3 ± 8.5 | 5.1 ± 4.0 |
| ApoB100 kinetic parameters | ||||||
| ApoB100 VLDL1 FCR (pools day−1) | 51.9 | 18.7 | 10.4 | 1.9 | 20.7 ± 19 | 15.3 ± 9.5 |
| ApoB100 VLDL1 FDC (pools day−1) | 33.1 | 13.4 | 9.2 | 0.6 | 14.1 ± 12 | 4.2 ± 3.5 |
| ApoB100 VLDL1 FTR (pools day−1) | 18.8 | 5.3 | 1.1 | 1.4 | 6.6 ± 7.2 | 11.2 ± 7 |
| ApoB100 VLDL1 prod (mg day−1) | 1080 | 960 | 987 | 559 | 890 ± 200 | 710 ± 130 |
| ApoB100 VLDL2 FCR (pools day−1) | 6.3 | 3.1 | 2.8 | 1 | 3.3 ± 1.9 | 3.8 ± 1.4 |
| ApoB100 VLDL2 prod (mg day−1) | 607 | 633 | 418 | 578 | 559 ± 84 | 765 ± 150 |
| ApoB100 VLDL2 dir prod (mg day−1) | 216 | 360 | 312 | 180 | 267 ± 72 | 266 ± 120 |
| ApoB100 VLDL tot prod (mg day−1) | 1296 | 1320 | 1272 | 739.2 | 1157 ± 240 | 976 ± 73 |
| ApoB100‐TG kinetic parameters | ||||||
| TG apoB100 VLDL1 FCR (pools day−1) | 58.6 | 20.4 | 12.1 | 2.3 | 23.4 ± 21 | 28.3 ± 20 |
| TG apoB100 VLDL1 FDC (pools day−1) | 43.1 | 15.3 | 11.6 | 1.5 | 17.9 ± 15 | 19.4 ± 15 |
| TG apoB100 VLDL1 FTR (pools day−1) | 15.5 | 5.1 | 0.6 | 0.8 | 5.5 ± 6.1 | 9.0 ± 5.7 |
| TG apoB100 VLDL1 prod (g day−1) | 31.3 | 27.8 | 29.1 | 14.7 | 25.7 ± 6.5 | 24.3 ± 11 |
| TG apoB100 VLDL2 FCR (pools day−1) | 33.8 | 17.6 | 4.6 | 2.8 | 14.7 ± 12 | 15.5 ± 10 |
| TG apoB100 VLDL2 prod (g day−1) | 12.9 | 16.2 | 5.3 | 7.5 | 10.5 ± 4.3 | 11.9 ± 2.3 |
| TG apoB100 VLDL2 dir prod (g day−1) | 4.6 | 9.2 | 4 | 2.3 | 5.0 ± 2.6 | 4.2 ± 1.9 |
| TG apoB100 VLDL tot prod (g day−1) | 35.9 | 37 | 33 | 17.1 | 31 ± 8 | 28.4 ± 11 |