Table 3.

The cause of death of pediatric patients with favorable alterations

RNA no.	Alterations	Mutations	Sex	Age, y	WBC, 109/L	FAB	Chromosome	Risks	Relapse	Cause of death
13	RUNX1-RUNX1T1	KIT	M	15.7	29.2	M2	46,XY,t(8;21)(q22;q22) [20]	Low	+	Acute GVHD grade
31	RUNX1-RUNX1T1	—	M	17.9	6.9	M2	45,X,-Y,t(8;21)(q22;q22)[18]/46,XY[2]	Low	+	Dyspnea due to GVHD and TMA
134	RUNX1-RUNX1T1	KIT	F	3.6	11.7	M2	46,XX,t(8;21)(q22;q22)[12]/46,XX[8]	Low	+	Infection, cardiac failure
146	RUNX1-RUNX1T1	—	M	5.4	9.8	RAEB-T	45,X,-Y,t(8;21)(q22;q22)[20]	Low	+	Primary disease
172	RUNX1-RUNX1T1	—	M	7.8	9.3	RAEB-T	45,X,-Y,t(8;21)(q22;q22)[19]/46,XY[1]	Low	+	Primary disease
200	RUNX1-RUNX1T1	KIT	F	6.1	18.7	M2	46,XX,t(8;14;21)(q22;q24;q22)[20]	Low	+	Primary disease
355	RUNX1-RUNX1T1	-	M	14.5	19.2	RAEB-T	46,XY,t(8;18;21)(q22;q21;q22)[12]/46,XY[2]	Low	+	Sepsis
383	RUNX1-RUNX1T1	KIT, RUNX1	M	9.9	38.7	M2	46,XY,t(8;19)(q22;p13) or t(8;19;21)(q22;p13;q22)[20]	Non-CR	−	Primary disease
209	CBFB-MYH11	FLT3-ITD	M	16.2	172.2	M4Eo	48,XY,+6,+8,inv(16)(p13q22)[8]/49, sl,+21[5]/ 50, sl1,+10[5]/49, sl2, +8[2]/49, sl3,+11[2]	Induction death	−	Intracranial hemorrhage (day 16)
26	biallelic CEBPA	—	M	6.8	10.7	M1	46,XY[20]	Intermediate	−	ARDS
97	NPM1	—	F	11.6	38.2	RAEB-T	47,XX,+18[1]/46,XX[19]	Intermediate	+	Primary disease