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. 2019 Nov 12;6(4):045008. doi: 10.1117/1.NPh.6.4.045008

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© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Fig. 2 — Imaging of extracellular $A β$ plaques in APP/PS1 mouse model. (a) Representative large-scale SHG/TPEF images and a corresponding $A β$ immunofluorescence image of a half hippocampal coronal plane. CC, corpus callosum; BV, blood vessel; HIP, hippocampus; CTX, cortex. (b) Enlarged images from yellow dashed box in (a). Yellow arrows, $A β$ plaque with strong TPEF signal and weak SHG signal. White arrows, $A β$ plaque with no SHG signal. (c) Emission spectrum from $A β$ plaque region (blue line) and adjacent region with no plaque (pink line). (d) Enlarged SHG/TPEF images from white dashed box in (a). Arrowhead, $A β$ plaque detected near the pial vessel. SHG, color-coded green. TPEF, color-coded red.