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. 2019 Nov 12;6(4):045008. doi: 10.1117/1.NPh.6.4.045008

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© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Fig. 4 — Progression of $A β$ deposition with age. (a) TPEF images of extracellular $A β$ plaques in CTX and HC from 2.5- to 12-month-old APP/PS1 mice. Arrow, $A β$ plaque. (b) TPEF image from wild-type mouse. (c) Statistical analysis revealed that $A β$ plaque number increases significantly with age. We performed ANOVA within groups. ^a $P < 0.01$ , versus 2.5-month-old group. ^b $P < 0.01$ , versus 3-month-old group. ^c $P < 0.05$ , versus 4-month-old group. ^d $P < 0.001$ , versus 6-month-old group. ^e $P < 0.001$ , versus 9-month-old group. Each group has three mice.