Skip to main content
. 2019 Mar 4;286(11):2135–2154. doi: 10.1111/febs.14790

Figure 9.

Figure 9

The effect of SCR0915 on wt MATα2 and MATα2 R264A activity. (A) SCR0915 inhibits wt MATα2 activity in the concentration‐dependent manner (B) SCR0915 recovers SAMe production in R264A mutant. (C) Half‐maximal inhibitory concentration of SCR0915 on wt MATα2 is determined (IC 50 = 282.8 nm). IC50 values were calculated from a log([SCR0911]) versus normalized response curve fit using graphpad prism version 5.00. (D) Thermal shift assay is used to determine R264A stability with and without 1 mm SCR0915 compound. (‘***’ indicates statistical significance at P < 0.001 compared with wt MATα2 alone). Data are mean ± SEM (n = 3).