Figure 1.

One‐stage clotting times of rFVIII, SI‐Emi, and BS‐027125. A, Dose response of SI‐Emi and SI‐Emi anti‐FIXa and anti‐FX homodimers (mixed and individually) compared to rFVIII. Black dotted line and gray shaded area are mean and range of steady‐state emicizumab concentration of patients receiving emicizumab prophylaxis, respectively.9, 17 B, Dose response of BS‐027125 and BS‐027125 anti‐FIXa and anti‐FX homodimers (mixed and individually) compared to rFVIII. Data are mean ± SD. anti‐FIXa, anti‐factor IXa; anti‐FX, anti‐factor X; BS‐027125, anti‐FIXa and anti‐FX antibodies BS‐125 and BS‐027; rFVIII, recombinant factor VIII; SI‐Emi, sequence identical emicizumab