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. 2019 Apr 26;17(7):1044–1052. doi: 10.1111/jth.14430

Figure 4.

Figure 4

Effect of phospholipid vesicle composition and concentration on FVIII‐equivalence of SI‐Emi and BS‐027125 in FXIa‐triggered TGA. A, Peak thrombin of rFVIII (0.3 IU/mL), SI‐Emi (300 nmol/L), and BS‐027125 (20 nmol/L) with increasing concentrations of PC:PS (80:20%) or PC:PE:PS (40:40:20%) vesicles. *P < 0.04 by t test. B, Interpolation of rFVIII peak thrombin standard curves with 95% confidence intervals on 40 μmol/L PC:PS or PC:PE:PS vesicles. C, Peak thrombin FVIII‐equivalence of SI‐Emi and BS‐027125 on 40 μmol/L PC:PS or PC:PE:PS vesicles. Data are mean ± SEM. BS‐027125, anti‐FIXa and anti‐FX antibodies BS‐125 and BS‐027; FVIII, factor VIII; FXIa, factor XIa; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PS, phosphatidylserine; rFVIII, recombinant factor VIII; SI‐Emi, sequence identical emicizumab; TGA, thrombin generation assay