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. 2019 Feb 19;61(5):343–352. doi: 10.1111/dgd.12597

Figure 4.

Figure 4

Co‐activation of multiple promoters by shared enhancers. (a) Organization of the endogenous eve locus in Drosophila. Insertion of synthetic Homie insulator‐lacZ construct induces re‐organization of genome configuration via Homie‐Homie insulator pairing, leading to co‐activation of eve and lacZ by endogenous stripe enhancers. (b) Pairing of insulators facilitates stable homolog association and co‐activation of two reporters by a shared enhancer