Figure 4.

Dermatitis in Flg^ft/ft mice is independent of type 2‐ and type 17‐associated effector cytokines. A,B, Indicated cytokines isolated from ear skin of age‐matched wild type (open bars) and Flg^ft/ft (red bars) depicted as pg cytokine per mg of total isolated protein. C, Macroscopic clinical scoring of wild‐type (dashed black), Flg^ft/ft (red), IL‐4^−/−Flg^ft/ft (black), IL‐5^−/−Flg^ft/ft (orange), IL‐9^−/−Flg^ft/ft (violet), and IL‐13^−/−Flg^ft/ft (blue) mice. Graph shows the mean + SEM from at least 8 mice per group. D, Macroscopic clinical scoring of wild‐type (dashed black), Flg^ft/ft (red), IL‐17A^−/−Flg^ft/ft (green), and IL‐22^−/−Flg^ft/ft (violet) mice. Graph shows the mean + SEM from at least 6 mice per group from two to three independent experiments