Figure 3.

The Utrecht score in canine adrenocortical tumours: Ki67 proliferation index, + 4 if ≥33% of tumour cells have clear/vacuolated cytoplasm, + 3 if necrosis is present. The images of the parameters shown here are from the adrenocortical tumour of one patient, which had the highest Utrecht score of our dataset. The adrenocortical tumour in this example had a Ki67 proliferation index of 22.2%, clear/vacuolated cytoplasm (small to very large vacuoles) in approximately 66% of tumour cells (so more than 33%), and fields of necrosis were present. This resulted in a total score of 22.2 + 4 + 3 = 29.2