Table 2.

Receiver Operating Characteristic Curve Analyses of Bilateral MCA PIs for Increased ICP and Decreased CPP at Different Thresholds

Parameter	Cutoff	AUC	95% CI	Sens/Spec, %	PPV/NPV, %	P
ICP ≥20 mm Hg
Ipsilateral MCA PI	1.34	0.751	0.645–0.839	50.0/90.6	89.6/52.7	<.0001
Contralateral MCA PI	1.35	0.668	0.550–0.772	40.8/92.6	89.4/50.5	.008
ICP ≥25 mm Hg
Ipsilateral MCA PI	1.32	0.671	0.560–0.770	55.9/76.0	61.3/71.7	.005
Contralateral MCA PI	1.04	0.599	0.480–0.710	69.7/53.5	53.5/69.7	.136
ICP ≥30 mm Hg
Ipsilateral MCA PI	1.32	0.669	0.558–0.768	60.9/72.1	45.2/83.0	.013
Contralateral MCA PI	1.48	0.596	0.477–0.707	39.1/84.9	53.0/76.2	.197
CPP <50 mm Hg
Ipsilateral MCA PI	1.58	0.742	0.635–0.831	50.0/89.2	38.5/93.0	.005
Contralateral MCA PI	1.53	0.545	0.427–0.660	36.4/83.1	26.8/88.5	.723
CPP <60 mm Hg
Ipsilateral MCA PI	1.32	0.628	0.516–0.731	53.3/72.2	51.6/73.6	.051
Contralateral MCA PI	0.99	0.500	0.383–0.617	43.3/71.7	45.0/66.0	.996
CPP <70 mm Hg
Ipsilateral MCA PI	1.34	0.616	0.503–0.720	47.8/81.6	75.9/56.3	.062
Contralateral MCA PI	0.79	0.492	0.375–0.609	88.6/21.9	60.9/58.3	.905

CI indicates confidence interval; NPV, negative predictive value; PPV, positive predictive value; Sens, sensitivity; and Spec, specificity.