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. 2019 Oct 10;160(12):2877–2891. doi: 10.1210/en.2019-00622

Figure 3.

Figure 3.

Proximal regulatory region‒mediated genomic regulation of Fgf23 expression by increased dietary intake of P. FGF23-PKO (PKO), FGF23-16KO (16KO), FGF23-38KO (38KO), and FGF23-IKO (IKO) mice and their wild-type (WT) littermates were fed P-deficient diets (0.02% P) at 5 wk of age for 1 wk and then fed either a P-deficient diet (gray bars) or a high-P diet (red bars) for 24 h. Serum P and iFGF23 levels and Fgf23 expression level in bone are presented. Gene expression level represents relative quantitation (RQ) normalized to Gapdh (ΔΔCT). Each value is the average of six mice per group, and error bars represent SEM. *P < 0.05 compared with P-deficient diet‒fed controls; #P < 0.05 compared with WT littermates fed the same diet.