Figure 2.

The role of macrophages in the development and progression of cancer (A) and possible regulatory effects of chondroitin‐6‐sulfate on functions of these cells in the tumor microenvironment (B). C‐6‐S, chondroitin‐6‐sulfate; ECM, extracellular matrix; HA, hyaluronan; HARE, HA receptor for endocytosis; HSPG, heparan sulfate proteoglycan; Hyal, hyaluronidase; IL, interleukin; MMP, matrix metalloproteinase; NF‐κB, nuclear factor‐κB; RNI, reactive nitrogen intermediates; ROS, reactive oxygen species; TGFβ, transforming growth factor β; TLR, Toll‐like receptor; TNFα, tumor necrosis factor α.