Table 1.
Comparison of HER2 IHC scores by manual scoring and DIA
| Manual scoring | ||||
|---|---|---|---|---|
| 0/1+ | 2+ | 3+ | Total | |
| Platform A DIA | ||||
| 0/1+ | 114 | 25 | 0 | 139 |
| 2+ | 0 | 1 | 1 | 2 |
| 3+ | 0 | 0 | 11 | 11 |
| Total | 114 | 26 | 12 | 152 |
| κ = 0.60 | ||||
| Manual scoring | ||||
|---|---|---|---|---|
| 0/1+ | 2+ | 3+ | Total | |
| Platform B DIA | ||||
| 0/1+ | 109 | 5 | 0 | 114 |
| 2+ | 5 | 19 | 0 | 24 |
| 3+ | 0 | 2 | 12 | 14 |
| Total | 114 | 26 | 12 | 152 |
| κ = 0.85 | ||||
| Platform B DIA | ||||
|---|---|---|---|---|
| 0/1+ | 2+ | 3+ | Total | |
| Platform A DIA | ||||
| 0/1+ | 114 | 24 | 1 | 139 |
| 2+ | 0 | 0 | 2 | 2 |
| 3+ | 0 | 0 | 11 | 11 |
| Total | 114 | 24 | 14 | 152 |
| κ = 0.58 | ||||
HER2, human epidermal growth factor 2; IHC, immunohistochemistry; DIA, digital image analysis; κ, linear weighted kappa.