Table 5.

Multivariable regression analyses for the prediction of high‐grade cancer in the follow‐up of 321 patients with previous non‐muscle‐invasive bladder cancer

Multivariable logistic regression analysis for positive Bladder EpiCheck				Multivariable logistic regression analysis for continuous Bladder EpiScore
	OR	95% CI	P		OR	95% CI	P
Last pathological stage (Ta reference category)
Tis	3.96	0.42–40.7	0.23		5.44	0.49–69.0	0.99
T1	3.43	0.63–23.1	0.17		5.62	0.88–46.9	0.17
High grade	1.00	0.18–4.97	0.99		0.64	0.09–3.54	0.08
Age (continuous)	0.98	0.93–1.05	0.63		0.97	0.91–1.04	0.62
Female gender	0.77	0.14–3.26	0.73		0.93	0.16–4.36	0.39
Time from last recurrence to urine collection	0.82	0.66–0.96	0.03		0.82	0.65–0.99	0.93
Ongoing intravesical therapy (never reference category)
No	0.95	0.22–4.09	0.94		0.82	0.06–2.33	0.81
Yes	0.40	0.06–2.07	0.29		0.40	0.06–2.33	0.32
AUC 72.7% (95% CI 62.7–76.6)
Positive EpiCheck	78.3	19.2–547	<0.001	EpiScore (continuous)	1.08	1.05–1.12	<0.001
AUC 94.9% (95% CI 88.3–96.8)				AUC 96.1% (95% CI 90.9–97.9)

AUC, area under the curve; OR, odds ratio.