Figure 5.

CHBRLs of Bmp2 and Tshz2 have limb bud‐specific enhancer function. Expression pattern of Bmp2 in (a–c) wild‐type and (d–f) Bmp2CHBRL ^−/− embryos. Facial Bmp2 expression was not altered in the same (a and d) Bmp2CHBRL ^−/− embryos. The dotted squares indicate the region exhibiting reduced Bmp2 expression in Bmp2CHBRL ^−/− embryos (compare b and e, c and f). Expression pattern of Tshz2 in (g–j) wild‐type and (k–n) Tshz2CHBRL ^−/− embryos. The arrowhead and arrow indicate the regions exhibiting reduced Tshz2 expression in Tshz2CHBRL ^−/− embryos