Table 4.
Response analyses per responder group: haematoxylin and eosin immunohistochemical staining of biopsies and viral load in biopsies and swabs
| Response | Complete (n = 3) | Partial (n = 6) | None (n = 11) |
|---|---|---|---|
| Swab baseline | |||
| HPV positive | TND (1/3)a | HPV2 (2/6) | HPV2 (3/11) |
| HPV3 (1/3) | HPV27 (2/6) | HPV27 (4/11) | |
| HPV57 (1/3) | HPV57 (2/6) | HPV57 (4/11) | |
| Mean log10 copies by PCR | 5·6b | 4·7 | 4·9 |
| Biopsy at the end of study | |||
| Viral characteristics present | 0/3 | 0/6 | 11/11 |
| Positive test for E4, Ki‐67 and HPV | E4 (0/3) | E4 (0/6) | E4 (11/11) |
| Ki‐67 (3/3)c | Ki‐67 (5/6),c (1/6)d | Ki‐67 (11/11)d | |
| HPV2 (1/3) | HPV2 (1/6) | HPV2 (4/11) | |
| HPV27 (1/6) | HPV27 (4/11) | ||
| HPV57 (3/6) | HPV57 (3/11) | ||
| Mean log10 copies by PCR | 2·9e | 3·8e | 8·8 |
| Swab at the end of study | |||
| HPV positive | HPV (0/3) | HPV2 (2/6) | HPV27 (4/11) |
| HPV57 (2/6) | HPV2 (4/11) | ||
| HPV57 (3/11) | |||
| Mean log10 copies by PCR | 0e | 1·1e , f | 4·3 |
The data are presented as n/N unless stated otherwise. HPV, human papillomavirus; PCR, polymerase chain reaction. aTarget not detected (TND) for the 23 HPV types included in the broad‐spectrum genotyping assay. bSamples of patients without HPV DNA detected or HPV3 at baseline were not further tested for viral load and therefore are not included in the mean. cBasal staining, restricted to the basal layer. dScattered staining. eSamples not tested are considered as zero. fSamples where the target is not detected are considered as zero.