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. 2019 Apr 3;127(5):288–302. doi: 10.1111/apm.12940

Figure 2.

Figure 2

Schematic depicting the domain structure of the most common anaplastic lymphoma kinase (ALK) fusions found in anaplastic large cell lymphoma (ALCL), inflammatory myofibroblastic tumors (IMTs) and non‐small cell lung cancer (NSCLC). Fusion partners mediate dimerization of the ALK‐fusion proteins resulting in constitutive activation of the ALK tyrosine kinase. Domains are highlighted as: oligomerization domain (OD, in blue), ALK protein tyrosine kinase (PTK, in red), coiled coil (CC, in green), HELP (lime green), WD40 (light green).