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. 2019 Apr 3;127(5):288–302. doi: 10.1111/apm.12940

Figure 3.

Figure 3

General overview of anaplastic lymphoma kinase (ALK) downstream signaling. ALK signaling can be activated in a ligand‐dependent (ALK wild‐type) or a ligand‐independent manner (ALK gain‐of‐function, ALK fusions, overexpression/amplification). ALK signals through multiple downstream pathways and stimulates the initiation of transcription to regulate specific cellular processes. The range of signaling pathways and cellular responses activated in response to ALK activation varies with cell type and ALK status (such as ALK fusion, overexpression or point mutation).