Table 2.
Associations between single nucleotide polymorphisms and diabetes risk in the Chinese populationa
| SNP | Diabetesb | IGTb | IFGb | FPGc |
|---|---|---|---|---|
| rs10401969 | 0.85 (0.52, 1.38) | 0.97 (0.60, 1.58) | 1.20 (0.78, 1.86) | −0.000 (−0.131, 0.131) |
| rs10830963 | 1.21 (0.92, 1.59) | 0.83 (0.62, 1.11) | 1.12 (0.84, 1.48) | 0.094 (0.016, 0.171)* |
| rs10842994 | 1.41 (0.97, 2.03) | 1.16 (0.81, 1.67) | 0.66 (0.48, 0.90)* | 0.074 (−0.024, 0.171) |
| rs10886471 | 1.37 (0.97, 1.94) | 1.68 (1.14, 2.50)* | 1.12 (0.79, 1.58) | 0.152 (0.057, 0.247) |
| rs10906115 | 1.01 (0.76, 1.34) | 1.17 (0.87, 1.57) | 0.88 (0.67, 1.17) | 0.009 (−0.070, 0.089) |
| rs10946398 | 1.59 (1.21, 2.08)* | 1.02 (0.77, 1.36) | 1.14 (0.86, 1.50) | 0.060 (−0.018, 0.138) |
| rs11257655 | 1.10 (0.83, 1.45) | 1.10 (0.82, 1.46) | 0.88 (0.66, 1.16) | 0.035 (−0.044, 0.113) |
| rs11634397 | 1.17 (0.78, 1.75) | 1.18 (0.77, 1.81) | 1.15 (0.75, 1.76) | 0.041 (−0.083, 0.164) |
| rs12454712 | 1.13 (0.87, 1.46) | 0.89 (0.68, 1.17) | 0.79 (0.61, 1.04) | 0.003 (−0.073, 0.079) |
| rs12970134 | 0.92 (0.64, 1.32) | 1.17 (0.83, 1.66) | 1.00 (0.70, 1.43) | −0.031 (−0.130, 0.067) |
| rs13266634 | 0.87 (0.66, 1.15) | 0.95 (0.72, 1.27) | 0.87 (0.66, 1.15) | −0.013 (−0.090, 0.065) |
| rs1470579 | 1.03 (0.76, 1.39) | 1.00 (0.73, 1.37) | 1.03 (0.76, 1.40) | 0.004 (−0.083, 0.090) |
| rs1535500 | 1.05 (0.81, 1.37) | 0.96 (0.73, 1.26) | 0.93 (0.71, 1.21) | 0.022 (−0.053, 0.097) |
| rs1552224 | 1.17 (0.73, 1.87) | 1.20 (0.72, 2.01) | 0.79 (0.51, 1.22) | 0.013 (−0.123, 0.150) |
| rs1558902 | 0.87 (0.58, 1.30) | 0.94 (0.62, 1.43) | 1.23 (0.85, 1.79) | −0.033 (−0.148, 0.081) |
| rs16861329 | 0.92 (0.67, 1.27) | 1.17 (0.85, 1.61) | 1.01 (0.73, 1.40) | −0.034 (−0.124, 0.055) |
| rs17584499 | 0.87 (0.55, 1.37) | 1.35 (0.91, 2.00) | 1.24 (0.83, 1.84) | 0.036 (−0.085, 0.157) |
| rs2028299 | 1.51 (1.13, 2.01)* | 1.32 (0.96, 1.80) | 0.87 (0.62, 1.23) | 0.098 (0.006, 0.190)* |
| rs2191349 | 0.95 (0.72, 1.24) | 0.73 (0.56, 0.96)* | 1.25 (0.94, 1.66) | 0.049 (−0.029, 0.128) |
| rs243021 | 0.96 (0.72, 1.26) | 1.07 (0.80, 1.44) | 1.09 (0.81, 1.46) | 0.019 (−0.061, 0.099) |
| rs2796441 | 1.11 (0.85, 1.44) | 1.02 (0.77, 1.36) | 0.87 (0.66, 1.15) | 0.030 (−0.047, 0.107) |
| rs2943641 | 1.15 (0.70, 1.91) | 0.66 (0.43, 1.03) | 1.08 (0.65, 1.79) | 0.006 (−0.133, 0.145) |
| rs340874 | 0.92 (0.70, 1.20) | 1.06 (0.80, 1.40) | 0.90 (0.68, 1.19) | −0.011 (−0.090, 0.067) |
| rs3794991 | 0.84 (0.49, 1.46) | 0.69 (0.36, 1.30) | 0.72 (0.39, 1.33) | 0.000 (−0.152, 0.153) |
| rs3923113 | 1.00 (0.69, 1.46) | 0.95 (0.65, 1.39) | 1.16 (0.78, 1.74) | 0.014 (−0.092, 0.120) |
| rs4430796 | 1.05 (0.78, 1.40) | 1.15 (0.85, 1.55) | 0.82 (0.60, 1.12) | 0.006 (−0.079, 0.090) |
| rs459193 | 0.94 (0.72, 1.22) | 1.10 (0.84, 1.45) | 1.00 (0.77, 1.31) | 0.032 (−0.044, 0.107) |
| rs4607103 | 0.90 (0.69, 1.18) | 1.12 (0.84, 1.48) | 0.91 (0.70, 1.20) | −0.064 (−0.140, 0.012) |
| rs4607517 | 0.82 (0.59, 1.14) | 1.10 (0.80, 1.52) | 1.03 (0.75, 1.42) | −0.030 (−0.121, 0.061) |
| rs4858889 | 0.68 (0.48, 0.96)* | 0.90 (0.61, 1.33) | 0.75 (0.53, 1.07) | −0.019 (−0.126, 0.089) |
| rs5015480 | 0.99 (0.70, 1.40) | 0.97 (0.68, 1.38) | 1.18 (0.84, 1.66) | −0.006 (−0.105, 0.092) |
| rs516946 | 1.61 (0.99, 2.60) | 1.05 (0.68, 1.60) | 0.87 (0.58, 1.30) | 0.146 (0.029, 0.263)* |
| rs5215 | 1.06 (0.80, 1.40) | 1.29 (0.97, 1.71) | 1.10 (0.83, 1.45) | −0.004 (−0.082, 0.074) |
| rs6815464 | 1.06 (0.80, 1.39) | 0.96 (0.73, 1.27) | 1.19 (0.90, 1.58) | 0.010 (−0.068, 0.088) |
| rs7041847 | 1.14 (0.87, 1.49) | 1.24 (0.93, 1.64) | 1.05 (0.79, 1.38) | 0.034 (−0.044, 0.111) |
| rs7172432 | 1.08 (0.82, 1.42) | 1.12 (0.84, 1.49) | 1.34 (0.99, 1.79) | 0.065 (−0.014, 0.144) |
| rs7178572 | 1.11 (0.85, 1.46) | 1.08 (0.82, 1.43) | 1.30 (0.98, 1.72) | 0.064 (−0.016, 0.144) |
| rs7202877 | 1.18 (0.84, 1.65) | 1.26 (0.88, 1.82) | 0.97 (0.69, 1.36) | 0.059 (−0.037, 0.156) |
| rs7403531 | 1.37 (1.04, 1.80)* | 0.75 (0.55, 1.02) | 1.16 (0.88, 1.54) | 0.127 (0.045, 0.209)* |
| rs7593730 | 1.05 (0.73, 1.50) | 0.99 (0.69, 1.42) | 0.76 (0.55, 1.06) | −0.041 (−0.137, 0.056) |
| rs7612463 | 1.02 (0.73, 1.41) | 1.07 (0.76, 1.52) | 1.11 (0.79, 1.57) | −0.015 (−0.106, 0.076) |
| rs780094 | 0.91 (0.69, 1.19) | 0.93 (0.70, 1.23) | 1.11 (0.84, 1.46) | 0.008 (−0.067, 0.083) |
| rs7961581 | 0.81 (0.57, 1.14) | 0.71 (0.50, 1.02) | 1.19 (0.87, 1.63) | 0.023 (−0.068, 0.114) |
| rs8050136 | 0.95 (0.64, 1.42) | 0.95 (0.62, 1.44) | 1.33 (0.91, 1.93) | −0.023 (−0.137, 0.091) |
| rs8090011 | 0.83 (0.63, 1.09) | 1.07 (0.79, 1.44) | 1.00 (0.74, 1.36) | −0.059 (−0.146, 0.027) |
| rs831571 | 0.81 (0.61, 1.08) | 0.79 (0.59, 1.05) | 0.97 (0.73, 1.28) | 0.033 (−0.046, 0.111) |
| rs864745 | 1.05 (0.76, 1.45) | 0.91 (0.66, 1.25) | 0.98 (0.71, 1.36) | 0.016 (−0.075, 0.106) |
| rs896854 | 0.94 (0.71, 1.24) | 0.83 (0.61, 1.12) | 1.08 (0.81, 1.43) | −0.028 (−0.108, 0.051) |
| rs9470794 | 1.16 (0.87, 1.55) | 1.71 (1.24, 2.38)* | 0.95 (0.72, 1.27) | 0.057 (−0.022, 0.136) |
| rs972283 | 0.96 (0.72, 1.30) | 0.90 (0.67, 1.22) | 1.03 (0.76, 1.39) | 0.017 (−0.068, 0.101) |
Abbreviations: IFG, impaired fasting glucose; IGT, impaired glucose tolerance; SNP, single nucleotide polymorphism.
a
After adjustment for age, sex, education, economic status, smoking, drinking, meat and poultry intake, cereal and bean intake, exercise, sedentary time, and body mass index.
b
Data are presented as odds ratios with 95% confidence intervals in parentheses.
c
Data are presented as β coefficients with 95% confidence intervals for increments of fasting plasma glucose (FPG).
*
P < 0.05.