Table 1.

Reported cases of Parvovirus B19 infection in heart transplant recipients (1993‐2018)

ID	Reference	Age (y)/Sex	Immuno‐suppressive therapy	Type of anemia	Reticulocyte count	Hgb before diagnosis	Transfusion‐dependent anemia	Parvo B19 PCR	Parvo B19 IgG and IgM	Therapy	Outcome
1	Nour et al6	1.8/F	TAC	N/A	0%	5.4 g/dL	N/A	N/A	N/A	No treatment	Good
2	Bergen et al7	53/F	CSA, PRED, AZA, MTX	N/A	0%	6.5 g/dl	Yes	Positive IHC and PCR in peripheral blood	N/A IgG and Positive IgM	IVIG 400 mg/kg for 5 d	Good
3	Thio et al8	10/F	CSA, MTX, PRED	N/A	N/A	5.5 g/dL	N/A	Positive PCR in peripheral blood	Negative IgG and Negative IgM	IVIG 400 mg/kg for 5 d	Good
4	Wicki et al9	29/M	CSA, AZA, PRED	N/A	N/A	4.8 g/dL	N/A	Positive PCR in peripheral blood	Positive IgG and Positive IgM	IVIG 400 mg/kg for 5 d	Good
5	Amiot et al10	61/M	CSA, MTX, PRED	N/A	Non‐detectable	5 g/dL	Yes	Positive PCR in peripheral blood and Bone marrow	Negative IgG and Negative IgM	No treatment	Good
6	Bisognano et al11	55/M	CSA, MMF, PRED	N/A	1.40%	7.2 g/dL	No	Not done	Negative IgG and Positive IgM	No treatment	Good
7	Lower et al12	57/F	TAC, MMF, PRED	N/A	"Low"	5.9 g/dL	Yes	Positive IHC in bone marrow	Positive IgG and Equivocal IgM	IVIG 30 000 mg/d for 5 d	Good
8	Eid et al13	34/M	N/A	N/A	N/A	6 g/dL	N/A	Positive IHC and PCR in peripheral blood	Negative IgG and Negative IgM	IVIG 1000 mg/kg for 2 d	Good
9	Fong et al14	29/F	"High‐dose immunosupp‐ression"	Normochromic Normocytic	0.04%	7.7 g/dL	N/A	Positive IHC and PCR in Bone marrow	Negative IgG and Negative IgM	IVIG 1000 mg/kg followed by IVIG 400 mg/kg every 4 wk	Good
10	Bansal et al15	12/F	TAC, SIR, PRED	N/A	<0.5%	3.2 g/dL	Yes	Positive PCR in peripheral blood > 10 billion DNA copies/mL	Negative IgG and positive IgM	IVIG 1000 mg/kg followed by IVIG every 2‐3 wk	Good
11	Kelleher et al16	11/M	TAC, MF, PRED	Normochromic Normocytic	Low	5.6 g/dL	Yes	Positive PCR in peripheral blood	N/A	IVIG 1000 mg/kg every 2 wk for 2 mo	Good
12	Invernizzi et al17	46/M	N/A	Normochromic Normocytic	Low	6.7 g/dL	N/A	Positive IHC and PCR in Bone marrow	N/A IgG and Positive IgM	High‐dose IVIG	Good
13	Sadigh and Frank18	66/M	TAC, MMF, PRED	N/A	0.20%	6.6 g/dL	Yes	Positive PCR in peripheral blood	Negative IgG and positive IgM	IVIG	Good
14	Shao et al19	30/M	N/A	N/A	N/A	6.3 g/dL	Yes	Positive pericardial fluid PCR and PCR peripheral blood	Negative IgG and positive IgM	IVIG for 2 d, every 4 wk for 8 mo	Good
15	Pinto et al (This article)	64/F	TAC, EVE, PRED	Microcytic	1.16%	6.3 g/dL	Yes	Positive PCR in peripheral blood > 100 million DNA copies/mL	N/A	IVIG 1000 mg/kg/d every day for 3 d	Good

AZA, azathioprine; CSA, cyclosporine; EVE, everolimus; HgB, hemoglobin; IHC, immunohistochemistry; MMF, mycophenolate mofetil; MTX, methotrexate; PCR, polymerase chain reaction; PRED, prednisone; SIR, sirolimus; TAC, tacrolimus.