Table 5.
Association between growth arrest‐specific gene 6 (Gas6) plasma level and overall mortality up to 36 months
| n/N (%) | Crude hazard ratio (95% confidence interval) | P‐value | Adjusted hazard ratio (95% confidence interval) | P‐value | |
|---|---|---|---|---|---|
| From the time of the index VTE (T1) onwards using Gas6 measured at the time of VTE diagnosis (T1) | |||||
| Gas6 at the time of the index VTE (categorized) | |||||
| Low (< 109%) | 20/216 (9.3) | Reference | Reference | ||
| Medium (109–157%) | 73/435 (16.8) | 1.96 (1.20–3.19) | 0.007 | 1.69 (1.00–2.84) | 0.048 |
| High (> 157%) | 77/213 (36.2) | 4.95 (3.04–8.05) | < 0.001 | 3.44 (2.03–5.82) | < 0.001 |
| Log‐transformed Gas6 at the time of the index VTE | |||||
| Continuous (per log unit) | 170/864 (19.7) | 7.21 (4.48–11.60) | < 0.001 | 5.00 (3.16–7.92) | < 0.001 |
| From the time of the index VTE onwards using Gas6 as a time‐varying covariate (at the time of the index VTE and 12 months later) | |||||
| Gas6 time‐varying covariate (categorized) | |||||
| Low (< 109%) | Reference | Reference | |||
| Medium (109–157%) | 1.88 (1.26–2.80) | 0.002 | 1.68 (1.09–2.57) | 0.017 | |
| High (> 157%) | 5.55 (3.63–8.47) | < 0.001 | 3.55 (2.21–5.71) | < 0.001 | |
| Log‐transformed Gas6 time‐varying covariate | |||||
| Continuous (per log unit) | 8.50 (5.51–13.11) | < 0.001 | 5.18 (3.17–8.46) | < 0.001 | |
VTE, venous thromboembolism. Adjustments: mortality was adjusted for age, gender, cancer, provoked VTE, prior VTE, overt pulmonary embolism, renal disease, history of major bleeding, heart failure, chronic lung disease, high pulse, low blood pressure, low oxygen, and periods of anticoagulation as a time‐varying covariate 49, 53.