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. 2019 Nov 8;14:8819–8834. doi: 10.2147/IJN.S217038

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© 2019 Liu et al.

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VEGF secretion inhibition by nanoparticles on HUVECs. (A) VEGF secretion at 12 h; (B) VEGF secretion at 24 h; (C) VEGF secretion at 48 h; (D) VEGF secretion at 72 h. Data are expressed as mean ± SD, n = 6. *p < 0.05, **p < 0.01 vs control without CoCl₂; #p < 0.05, ##p < 0.01, ###p < 0.001 vs control with CoCl₂; ^p < 0.05, ^^p < 0.01 vs eBev-DPPNs with CoCl_2.

Abbreviations: VEGF, vascular endothelial growth factor; eBev-DPPNs, electrostatically-conjugated bevacizumab-bearing DPPNs; cBev-DPNs, chemically-conjugated bevacizumab-bearing DPNs.